Phe-Arg-βNA (hydrochloride)

Phe-Arg-βNA is a peptide broad-spectrum bacterial efflux pump inhibitor.1 It potentiates the activity of the fluoroquinolone antibiotic levofloxacin (Item No. 20382) against P. aeruginosa strains overexpressing the MexAB-OprM, MexCD-OprJ, or MexEF-OprN multidrug resistance efflux pumps (EC50s = 10 µg/ml for all) but is inactive against these strains when used alone (MICs = >512 µg/ml for all). Phe-Arg-βNA also increases the susceptibility of quinolone-resistant E. coli isolates to nalidixic acid (Item No. 19807).2WARNING This product is not for human or veterinary use.

A broad-spectrum bacterial efflux pump inhibitor

519.5

≥98%

Biochemicals/Peptides/Transporter & Exchanger Modulators

Formal_Name:L-phenylalanyl-N-2-naphthalenyl-L-argininamide, dihydrochloride

O=C(N[C@H](C(NC1=CC=C(C=CC=C2)C2=C1)=O)CCCNC(N)=N)[C@@H](N)CC3=CC=CC=C3.Cl.Cl

C25H30N6O2 • 2HCl

100929-99-5

≥ 4 years

DMF: 10mg/mL DMSO: 10mg/mL Ethanol: 2mg/mL PBS (pH 7.2): 3mg/mL