AM 580

AM 580 is a selective retinoic acid analog, which is useful in vitro as a RARα agonist. Studies indicate that RARα increases the signaling of the RARα receptor to prevent intracellular and extracellular amyloid-β accumulation. In addition, this receptor increases the expression of disintegrin and metalloprotease. Since amyloid-β accumulation is a major finding in Alzheimer's disease (AD), AM 580 can be used to study this disease in vitro. AM 580 also induces the functions of IL-4, IL-5 and IL-13 and suppresses the production of IL-12 and IFNγ. Alternate studies suggest that AM 580 inhibits tumor proliferation by reducing the level of RARγ and activates RAR β. 参考文献 1. Kagechika, H., et al., 1988. Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity. Journal of medicinal chemistry. 31(11): 2182-92. PMID: 3184125 2. Charton, Julie., et al., 2009. Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives. Bioorganic & medicinal chemistry letters. 19(2): 489-92. PMID: 19058965 3. Jarvis, C I., et al., 2010. Retinoic acid receptor-α signalling antagonizes both intracellular and extracellular amyloid-β production and prevents neuronal cell death caused by amyloid-β. The European journal of neuroscience. 32(8): 1246-55. PMID: 20950278

351.44

crystalline

AM 580 is a retinoic acid analog and selective RARα agonist

4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid

CC1(CCC(C2=C1C=CC(=C2)C(=O)NC3=CC=C(C=C3)C(=O)O)(C)C)C

C22H25NO3