AS-101

AS-101 is an immunomodulator.1 It inhibits IL-10 secretion from and cell proliferation of IL-10-secreting human stomach adenocarcinoma and glioblastoma multiforme (GBM) cells when used at concentrations ranging from 0.5 to 2.5 µg/ml, an effect that can be blocked by the addition of recombinant IL-10. It reverses IL-10-induced increases in phosphorylated Stat3 and reduces the expression of Bcl-2 in B16 murine melanoma cells. AS-101 sensitizes GBM cells to paclitaxel (Item No. 10461), doxorubicin (Item No. 15007), and 5-fluorouracil (5-FU; Item No. 14416) in vitro and to paclitaxel in a GBM mouse xenograft model when administered at a dose of 0.5 mg/kg per day. AS-101 (1 mg/kg) also prevents infiltration of CD49d+ cells and decreases the expression of IL-6, TNF-α, IL-1β, and MCP-1 in the spinal cord, as well as delays onset and slows the progression of symptoms in a mouse model of experimental autoimmune encephalomyelitis (EAE).2WARNING This product is not for human or veterinary use.

An immunomodulator

312.0

≥95%

Biochemicals

Formal_Name:(SP-5-22)-trichloro[1,2-ethanediolato(2-)-κO1,κO2]-tellurate(1-), monoammonium salt

[Cl-][Te+4]1([Cl-])([O]CC[O]1)[Cl-].[NH4+]

C2H4Cl3O2Te • NH4

106566-58-9

≥ 4 years

DMF: 30 mg/ml DMSO: 30 mg/ml DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml Ethanol: Slightly soluble