Demethylzeylasteral

Demethylzeylasteral is a nortriterpenoid originally isolated from T. wilfordii that has diverse biological activities, including enzyme inhibitory, anti-angiogenic, antiproliferative, anti-inflammatory, and immunosuppressive properties.1,2,3,4 Demethylzeylasteral inhibits the UDP-glucuronosyltransferase (UGT) isoforms UGT1A6 and UGT2B7 (Kis = 0.6 and 17.3 μM, respectively).2 It inhibits growth of bovine aortic endothelial cells (BAEs) and U251 human glioma cancer cells in vitro (IC50s = 0.21 and ~6.2 μM, respectively), as well as inhibits tumor growth and neovascularization in vivo in a B16/F10 melanoma mouse allograft model when administered at a dose of 30 mg/kg per day.1 Demethylzeylasteral (0.12 mg/kg per day) decreases renal proteinuria, lesions, immune cell infiltration, and protein levels of TNF-α, COX-2, and ICAM-1 in lupus-prone MRL/lpr mice.3 Demethylzeylasteral (10 mg/kg per day) also increases survival of recipient rats in a model of kidney transplant.4WARNING This product is not for human or veterinary use.

A nortriterpenoid with diverse biological activities

480.6

≥98%

Biochemicals,Lipids/Prenol Lipids,Natural Products/Terpenes

Formal_Name:(9β,13α,14β,20α)-2,3-dihydroxy-9,13-dimethyl-6,23-dioxo-24,25,26-trinoroleana-1,3,5(10),7-tetraen-29-oic acid

O=CC1=C(C(C=C2[C@@]3(C)CC[C@]4(C)[C@]2(C)CC[C@]5(C)[C@@]4([H])C[C@@](C(O)=O)(C)CC5)=O)C3=CC(O)=C1O

C29H36O6

107316-88-1

≥ 4 years

DMF: 30 mg/ml DMSO: 30 mg/ml DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml Ethanol: 10 mg/ml