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产品介绍
产品介绍
产品信息
简单描述
A motilin receptor agonist
商品描述
EM574 is a motilin receptor agonist with an IC50 value of 6.17 nM for binding to rabbit gastric antral smooth muscle homogenates in a radioligand binding assay.1 It also binds to human smooth muscle homogenates in a radioligand binding assay (Kd = 7.8 nM).2 EM574 induces contraction of isolated rabbit, but not rat or guinea pig, intestine (EC50 = 5.5 nM).1 It increases antral motility and enhances gastric emptying in canine models of gastroparesis when administered intraduodenally at a dose of 0.03 mg/kg following a semi-solid meal.3
分子量
744
纯度
≥98%
背景
别名
Idremcinal
结构式
CC[C@H]([C@](O)(C)[C@H](O)[C@@H](C)C1=C(C)C[C@](O1)(C)[C@]([H])(O[C@@]2([H])[C@H](O)[C@@H](N(C(C)C)C)C[C@@H](C)O2)[C@@H](C)[C@@](O[C@]3([H])O[C@@H](C)[C@H](O)[C@](C)(OC)C3)([H])[C@H]4C)OC4=O
分子式
C39H69NO12
CAS号
110480-13-2
制备和贮存
保存
≥ 4 years
溶解方法
DMSO: soluble
Ethanol: soluble
Methanol: soluble
保存方式
-20°C
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