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Amlodipine besylate
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产品介绍
产品介绍
产品信息
简单描述
Amlodipine besylate is an L-type calcium channel protein inhibitor and blocker that contains antihypertensive properties. Amlodipine besylate also displays vasoprotective effects in cardiovascular disease and inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM). Amlodipine besylate has been shown to inhibit proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC50 = 25 μM).
参考文献 1. Arrowsmith, J.E., et al. 1986. J. Med. Chem. 29: 1696-1702. PMID: 2943898 2. Burges, R.A., et al. 1987. J. Cardiovasc. Pharmacol. 9: 110-119. PMID: 2434785 3. Packer, M., et al. 1996. N. Engl. J. Med. 335: 1107-1114. PMID: 8813041 4. Yoshida, J., et al. 2003. Eur. J. Pharmacol. 472: 23-31. PMID: 12860469 5. Toba, H., et al. 2005 Hypertens. Res. 28: 689-700. PMID: 16392774
分子量
567.05
纯度
≥98%
外观
crystalline powder
应用
实验应用
Amlodipine besylate is a calcium channel protein inhibitor
背景
结构式
CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC=C(C=C1)S(=O)(=O)O
分子式
C20H25ClN2O5 C6H6O3S
CAS号
111470-99-6
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