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Ambenonium (chloride)
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产品介绍
产品介绍
产品信息
简单描述
Ambenonium is an inhibitor of acetylcholinesterase (AChE; IC50 = 0.7 nM).1 It is selective for AChE over butyrylcholinesterase (BChE; IC50 = 6.82 µM). Ambenonium (10 µM) increases the secretion of amyloid precursor protein (APP) in primary rat basal forebrain cells.2 It induces repetitive firing of electrically stimulated gastrocnemius muscle in anesthetized cats when administered intra-arterially at a dose of 5 µg/animal.3 Ambenonium (3 µg/animal) inhibits paralysis induced by the neuromuscular blocking agents tubocurarine or decamethonium (Item No. 24907) in anesthetized cats.4 Formulations containing ambenonium have previously been used in the treatment of myasthenia gravis.WARNING This product is not for human or veterinary use.
商品描述
An AChE inhibitor
分子量
608.5
纯度
≥95%
产品类型
Biochemicals/Small Molecule Inhibitors/Acetylcholine Turnover
背景
别名
Formal_Name:N,N′-[(1,2-dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis[2-chloro-N,N-diethyl-benzenemethanaminium, dichloride;Synonyms:WIN 8,077
研究领域
Immunology & Inflammation/Autoimmunity,Neuroscience/Neurodegenerative Disorders/Alzheimer’s Disease
结构式
O=C(C(NCC[N+](CC)(CC)CC1=C(C=CC=C1)Cl)=O)NCC[N+](CC)(CC)CC2=C(C=CC=C2)Cl.[Cl-].[Cl-]
分子式
C28H42Cl2N4O2 • 2Cl
CAS号
115-79-7
制备和贮存
保存
≥ 4 years
溶解方法
Acetonitrile: Slightly Soluble: 0.1-1 mg/ml
Water: Slightly Soluble: 0.1-1 mg/ml
保存方式
-20°C
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