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IXA4
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产品介绍
产品介绍
产品信息
简单描述
IXA4 is an activator of inositol-requiring enzyme 1 (IRE1).1 It induces the expression of the Ire1 target Xpb1s in primary mouse hepatocytes. In vivo, IXA4 (50 mg/kg) decreases hepatic expression of the Xbp1 target gene Dnajb9 in wild-type mice and a mouse model of high-fat diet-induced obesity, effects that can be reversed by the IRE1 inhibitor STF-083010 (Item No. 17370). IXA4 also increases glucose tolerance and suppresses hepatic gluconeogenesis and steatosis in a mouse model of high-fat diet-induced obesity.WARNING This product is not for human or veterinary use.
商品描述
An activator of IRE1
分子量
436.5
纯度
≥98%
产品类型
Biochemicals/Small Molecule Activators
背景
别名
Formal_Name:N-methyl-N-[2-(4-methylphenoxy)ethyl]-4-[(1-oxo-3-phenoxypropyl)amino]-1H-pyrazole-1-acetamide
研究领域
Cell Biology/Endomembrane System & Vesicular Trafficking/ER Protein Folding,Endocrinology & Metabolism/Metabolic Diseases/Diabetes/Obesity
结构式
O=C(N(C)CCOC1=CC=C(C)C=C1)CN2N=CC(NC(CCOC3=CC=CC=C3)=O)=C2
分子式
C24H28N4O4
CAS号
1185329-96-7
制备和贮存
保存
≥ 4 years
溶解方法
DMF: 10 mg/mL
DMSO: 10 mg/mL
PBS (pH 7.2): 0.3 mg/mL
保存方式
-20°C
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