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DLin-KC2-DMA
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产品介绍
产品信息
简单描述
An ionizable cationic lipid
商品描述
DLin-KC2-DMA is an ionizable cationic lipid (apparent pKa = 6.7) that has been used in the formation of lipid nanoparticles (LNPs) encapsulating siRNA or plasmid DNA for use in vitro and in vivo.1,2 LNPs containing DLin-KC2-DMA selectively accumulate in the liver after intravenous or intramuscular administration in mice or localize to the retinal pigment epithelium and Müller glia after subretinal administration.2,3 DLin-KC2-DMA-containing LNPs encapsulating siRNA targeting F7 mRNA, which encodes Factor VII, reduce serum Factor VII levels in mice.1 Intravenous administration of DLin-KC2-DMA-containing LNPs encapsulating siRNA targeting AR mRNA, which encodes the androgen receptor, decrease serum prostate-specific antigen (PSA) and tumor androgen receptor levels in an LNCaP prostate cancer mouse xenograft model.4
分子量
642.1
纯度
≥98%
组成成分
二甲基2，2-二-(9Z，12Z)-9，12-十八碳二烯-1-基-1，3-二氧戊环-4-乙胺≥98%杂质≤2%
背景
别名
KC2
结构式
CCCCC/C=C\C/C=C\CCCCCCCCC1(OC(CCN(C)C)CO1)CCCCCCCC/C=C\C/C=C\CCCCC
分子式
C43H79NO2
CAS号
1190197-97-7
制备和贮存
保存
≥ 2 years
溶解方法
DMSO: Soluble
保存方式
-20°C
数据库链接
UN No.
1170
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