Cyprodinil

An anilinopyrimidine fungicide

Cyprodinil is an anilinopyrimidine broad-spectrum fungicide that inhibits the biosynthesis of methionine in phytopathogenic fungi.1 It inhibits mycelial cell growth of B. cinerea, P. herpotrichoides, and H. oryzae on amino acid-free media (IC50s = 0.44, 4.8, and 0.03 µM, respectively), an effect that is reversed by addition of methionine or homocysteine. In an MDA-kb2 assay, cyprodinil acts as an androgen receptor (AR) agonist (EC20 = 1.91 µM) in the absence of the AR agonist DHT and inhibits the androgenic effect of DHT (IC20 = 15.1 µM).2 It is cytotoxic in a yeast antiandrogen screen (YAS; EC20 = 27.8 µM) but not in an MDA-kb2 assay (EC20 = >50 µM). Cyprodinil increases proliferation of estrogen receptor-expressing BG-1 ovarian cancer cells when used at low micromolar concentrations in combination with 17β-estradiol.3 It also increases tumor mass in a BG-1 ovariectomized mouse xenograft model after 70 days when administered at a dose of 3 mg/kg every three days. Formulations containing cyprodinil have been used in the control of fungi in agriculture.

225.3

≥95%

CC1=CC(C2CC2)=NC(NC3=CC=CC=C3)=N1

C14H15N3

121552-61-2

≥ 4 years

Chloroform: Slightly Soluble

3077