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PNU 282987
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产品介绍
产品介绍
产品信息
纯化方式
>98%
抗原名称
α7 nAChR
来源纯化
Synthetic
产品详情
Selective Agonist of α7 nAChR
商品描述
PNU 282987 (#P-110) is a highly pure, synthetic, and biologically active compound.
分子量
264.75
生物活性
PNU 282987 is a selective agonist of α7 nicotinic acetylcholine receptor (nAChR)1-2, with an EC50 of 5.6 μM in Xenopus oocytes3 and Ki of 26 nM in rat α7 nAChR1. Via modulating/enhancing hippocampal GABAergic neurotransmission, PNU 282987 improves auditory gating and enhances hippocampal oscillatory activity and therefore may offer a potential pharmacotherapy in the treatment of schizophrenia1.
可溶性
DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
浓度
EC50 ~ 5 μM.
形式
Lyophilized
背景
分子式
C14H17ClN2O.
CAS号
123464-89-1
制备和贮存
存储溶液
Up to one week at 4°C or three months at -20°C.
保存方式
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
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