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产品介绍
产品信息
纯化方式
>97%
抗原名称
NaV1.7 channels
来源纯化
Synthetic
产品详情
A Potent and Selective Blocker of NaV1.7 Channel
商品描述
PF-05089771 (#P-315) is a highly pure, synthetic, and biologically active compound.
分子量
500.34
生物活性
PF-05089771 is a novel, potent, state-dependent and selective inhibitor of NaV1.7, shown to inhibit half-inactivated human NaV1.7 channels with IC50 of 11 nM via interaction with the domain IV, and tested for clinical application in human microdose studies1-3.
可溶性
Up to 50 mM in DMSO, also soluble in methanol.Centrifuge all product preparations before use (10000 x g 5 min).
浓度
10 nM – 1 µM.
形式
Lyophilized
组成成分
4-(2-(3-氨基-1H-吡唑-4-基)-4-氯苯氧基)-5-氯-2-氟-N-(噻唑-4-基)苯磺酰胺>97%
背景
分子式
C18H12Cl2FN5O3S2.
CAS号
1235403-62-9
制备和贮存
存储溶液
-20°C.
保存方式
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
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