Oleic Acid-13C5

Oleic acid-13C5 is intended for use as an internal standard for the quantification of oleic acid (Item Nos. 90260 | 24659) by GC- or LC-MS. Oleic acid is a monounsaturated fatty acid and a major component of membrane phospholipids that has been found in human plasma, cell membranes, and adipose tissue.1,2 It contributes approximately 17% of the total fatty acids esterified to phosphatidylcholine, the major phospholipid class in porcine platelets.1 Oleic acid inhibits collagen-stimulated platelet aggregation by approximately 90% when used at a concentration of 10 µg/ml. It also inhibits fMLF-induced neutrophil aggregation and degranulation by 55 and 68%, respectively, when used at a concentration of 5 µM, similar to arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607).3 Oleic acid (60 µM) induces release of intracellular calcium in human platelets.4 In vivo, oleic acid increases TNF-α, IL-8, IL-6, and IL-1β production, neutrophil accumulation, and apoptotic and necrotic cell death in mouse lung and has been used to induce lung injury in a mouse model of acute respiratory distress syndrome (ARDS).2WARNING This product is not for human or veterinary use.

An internal standard for the quantification of oleic acid

287.4

≥95%

Biochemicals/Analytical Standards/Isotopically Labeled Standards/13C,Lipids/Fatty Acids/Octadecanoids

Mass Spectrometry

Formal_Name:oleic-1,2,3,7,8-13C5 acid;Synonyms:9Z-Octadecenoic Acid-13C5 C18:1(9Z)-13C5 cis-9-Octadecenoic Acid-13C5 FA 18:1-13C

CCCCCCCC/C=C\[13CH2][13CH2]CCC[13CH2][13CH2][13C](O)=O

C13[13C]5H34O2

1255644-48-4

≥ 2 years

Chloroform: Soluble DMF: >100 mg/ml DMSO: >100 mg/ml Ethanol: >100 mg/ml PBS (pH 7.2): <100 µg/ml