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TRX-818 (sodium salt)
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产品介绍
产品介绍
产品信息
简单描述
TRX-818 is an anticancer compound.1,2 It inhibits vasculogenic mimicry network formation in C8161 and SK-MEL-28 melanoma cells when used at concentrations ranging from less than or equal to 5 to 10 nM. 1 TRX-818 (10 nM) decreases pro-Nodal protein levels and Smad2 phosphorylation in C8161 cells. It reduces tumor volume with a minimum effective dose (MED) value of 50 mg/kg and decreases the number of vasculogenic mimicry channels in tumors when administered at a dose of 100 mg/kg in an HCT116 colon cancer mouse xenograft model. TRX-818 (7.5, 15, and 30 mg/kg) reduces tumor growth in a Hep3B mouse xenograft model in a dose-dependent manner.2WARNING This product is not for human or veterinary use.
商品描述
An anticancer compound
分子量
409.2
纯度
≥98%
产品类型
Biochemicals
背景
别名
Formal_Name:2-(3-fluorophenyl)-6-methoxy-5-(phosphonooxy)-4(1H)-quinolinone, disodium salt
研究领域
Cancer/Angiogenesis/Cell Death/Apoptosis
结构式
O=C1C2=C(C=CC(OC)=C2OP([O-])([O-])=O)NC(C3=CC(F)=CC=C3)=C1.[Na+].[Na+]
分子式
C16H11FNO6P • 2Na
CAS号
1256037-62-3
制备和贮存
保存
≥ 4 years
溶解方法
DMF: 10 mg/ml
DMSO: 10 mg/ml
Ethanol: 1 mg/ml
PBS (pH 7.2): 0.5 mg/ml
保存方式
-20°C
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