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TAS 116
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产品介绍
产品介绍
产品信息
简单描述
TAS 116 is a heat shock protein 90 (Hsp90) inhibitor.1 It selectively binds to Hsp90α and Hsp90β (Kis = 34.7 and 21.3 nM, respectively) over glucose-regulated protein 94 (GRP94) and TGF-β receptor-associated protein 1 (TRAP1; Kis = 50,000 nM for both). TAS 116 (3.6, 7.1, and 14 mg/kg) reduces intratumoral protein levels of HER2, HER3, and Akt, as well as reduces tumor growth in a HER2-expressing NCI N87 gastric cancer mouse xenograft model and does not induce photoreceptor injury in rats when administered at a dose of 12 mg/kg per day.WARNING This product is not for human or veterinary use.
商品描述
An Hsp90 inhibitor
分子量
454.5
纯度
≥95%
产品类型
Biochemicals/Small Molecule Inhibitors/Heat Shock Proteins
背景
别名
Formal_Name:3-ethyl-4-[3-(1-methylethyl)-4-[4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl]-1H-pyrazolo[3,4-b]pyridin-1-yl]-benzamide
研究领域
Cancer/Cell Signaling/Growth Factor Receptor Signaling/PI3K/Akt/mTOR Signaling,Cell Biology/Cellular Chaperones
结构式
O=C(C1=CC=C(N2N=C(C(C)C)C3=C(N4C=NC(C5=CN(C)N=C5)=C4)C=CN=C32)C(CC)=C1)N
分子式
C25H26N8O
CAS号
1260533-36-5
制备和贮存
保存
≥ 4 years
溶解方法
DMSO: soluble
保存方式
-20°C
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