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产品介绍
产品介绍
产品信息
简单描述
An orally bioavailable pan-Akt inhibitor
商品描述
ARQ 092 is an allosteric, orally bioavailable, pan-Akt inhibitor (IC50s = 5.0, 4.5, and 16 nM for Akt1, Akt2, and Akt3, respectively).1 It is selective for Akt isoforms over a panel of 303 other kinases.1 ARQ 092 binds inactive Akt and prevents membrane localization and full Akt activation.1,2 It also directly inhibits the membrane-associated active form of Akt, preventing phosphorylation of downstream targets.1,2 ARQ 092 inhibits the proliferation of a wide range of cancer cells in vitro, inhibits the mutated Akt form found in Proteus syndrome, and attenuates heterotypic cell-cell interactions in a mouse model of sickle cell disease.1,2,3,4
分子量
432.5
纯度
≥98%
背景
结构式
NC1=NC=CC=C1C2=NC(C=C3)=C(N2C4=CC=C(C5(N)CCC5)C=C4)N=C3C6=CC=CC=C6
分子式
C27H24N6
CAS号
1313881-70-7
制备和贮存
保存
≥ 4 years
溶解方法
DMF: 12.5 mg/ml
DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml
DMSO: 10 mg/ml
Ethanol: 0.3 mg/ml
保存方式
-20°C
参考图片
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