CB-1158 analog (hydrochloride)

CB-1158 is an inhibitor of arginase I and II (IC50s = 0.086 and 0.296 µM for the human enzymes, respectively).1 It is selective for arginase I and II over neuronal nitric oxide synthase (nNOS), endothelial NOS (eNOS), and inducible NOS (iNOS; IC50s = >50 µM for all). CB-1158 reverses inhibition of T cell proliferation induced by granulocytes in vitro (IC50 = 0.204 µM). It reduces tumor growth in a CT26 murine colon cancer model when administered at a dose of 100 mg/kg twice per day.WARNING This product is not for human or veterinary use.

An arginase inhibitor

417.1

≥95%

Biochemicals/Small Molecule Inhibitors

Formal_Name:α-amino-α-(4-boronobutyl)-1-[(2,4-dichlorophenyl)methyl]-4-piperidineacetic acid;Synonyms:INCB 01158 Numidargistat

ClC1=CC(Cl)=C(CN2CCC(C(C(O)=O)(N)CCCCB(O)O)CC2)C=C1

C18H27BCl2N2O4

1345810-21-0

≥ 4 years

DMSO: soluble