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AC-710
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产品介绍
产品介绍
产品信息
简单描述
AC-710 is an inhibitor of PDGFR family kinases (IC50s = 7.7, 10.5, 2, and 1.2 nM for PDGFRβ, CSF1R, FLT3, and c-Kit, respectively).1 It is greater than 30-fold selective for PDGFR family kinases over a panel of 386 kinases, as well as over a panel of five cytochrome P450 (CYP) enzymes (IC50s = >40 µM). AC-710 (30 mg/kg) inhibits CSF1R-dependent M-NFS-60 murine leukemia cell proliferation and reduces tumor volume in an FLT3 mutant MV4-11 leukemia mouse xenograft model.WARNING This product is not for human or veterinary use.
商品描述
A PDGFR family kinase inhibitor
分子量
562.7
纯度
≥98%
产品类型
Biochemicals/Kinase Inhibitors/PDGFR Family/Small Molecule Inhibitors/Kinases
背景
别名
Formal_Name:N-[4-[[[[5-(1,1-dimethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-2-pyridinecarboxamide
研究领域
Cancer/Cell Signaling
结构式
CCN1C(C)(C)CC(OC2=CC=C(C(NC3=CC=C(NC(NC4=NOC(C(C)(C)C)=C4)=O)C=C3)=O)N=C2)CC1(C)C
分子式
C31H42N6O4
CAS号
1351522-04-7
制备和贮存
保存
≥ 4 years
溶解方法
DMF: 10 mg/ml
保存方式
-20°C
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