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L-319
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产品介绍
产品信息
简单描述
An ionizable cationic and biodegradable lipid derivative of DLin-MC3-DMA
商品描述
L-319 is an ionizable cationic (pKa = 6.38) and biodegradable lipid derivative of DLin-MC3-DMA (Item No. 34364) that has been used in the formation of lipid nanoparticles (LNPs).1 LNPs containing L-319 and encapsulating siRNA encoding Factor VII (FVII) reduce serum levels of FVII in mice. LNPs containing L-319 in combination with cKK-E12 (Item No. 36700) and encapsulating varicella-zoster virus (VZV) mRNA encoding glycoprotein E (gE) increase the lymph node and spleen levels of CD11c+CD80+ and CD11c+CD86+ cells and total serum IgG titers in mice, as well as decrease the number of VZV-induced rashes and the epithelial levels of VZV DNA, in a guinea pig model of VZV-induced shingles.2
分子量
678
纯度
≥95%
组成成分
9-[4-(二甲氨基)-1-氧丁氧基]-十七烷二酸，1，17-二-(2Z)-2-壬烯-1-基酯≥95%杂质≤5%
背景
结构式
CN(C)CCCC(OC(CCCCCCCC(OC/C=C\CCCCCC)=O)CCCCCCCC(OC/C=C\CCCCCC)=O)=O
分子式
C41H75NO6
CAS号
1351586-50-9
制备和贮存
保存
≥ 2 years
溶解方法
Chloroform: Soluble
Ethanol: Soluble
保存方式
-20°C
数据库链接
UN No.
1170
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