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1-Methylpseudouridine
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产品介绍
产品介绍
产品信息
简单描述
A nucleoside analog
商品描述
1-Methylpseudouridine is a nucleoside analog that has been found in Streptomyces platensis.1 It increases the thermodynamic and biological stability of RNA.2,3,4 Unlike unmodified mRNA, 1-methylpseudouridine-containing mRNA does not induce IFN-β secretion in A549 cells, indicating low immunogenicity.3 Intramuscular or intradermal administration of luciferase mRNA containing 1-methylpseudouridine via lipid complexes increases luciferase activity in mice. Formulations containing 1-methylpseudouridine incorporated into mRNA have been used in the development of mRNA-based vaccines.
分子量
258.2
纯度
≥98%
背景
别名
m1ψ|N1-Methylpseudouridine|N1-methyl-ψ|NSC 240023|U-50228
结构式
O[C@H]1[C@@H](O)[C@@](C2=CN(C)C(NC2=O)=O)([H])O[C@@H]1CO
分子式
C10H14N2O6
CAS号
13860-38-3
制备和贮存
保存
≥ 4 years
溶解方法
DMF: 3 mg/ml
DMSO: 10 mg/ml
PBS (pH 7.2): 5 mg/ml
保存方式
-20°C
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