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产品介绍
产品介绍
产品信息
商品描述
EDHF (endothelium-derived hyperpolarizing factor), an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin, is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators. CYP450 metabolism of polyunsaturated fatty acids produces epoxides such as 14(15)-EpETrE which are prime candidates for the actual active mediator. However, the CYP450 metabolites of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been little studied relative to arachidonate epoxygenase metabolites. 14(15)-EpETE is the ω-3 homolog of 14(15)-EpETrE, derived via epoxidation of the 14,15-double bond of EPA. The EDHF activity of 14(15)-EpETE has not yet been determined.
分子量
318.5
纯度
≥90%
可溶性
Soluble in water (1 mg/ml at 25° C), PBS (pH 7.2) (~1 mg/ml), DMSO (~50 mg/ml), DMF (~50 mg/ml), and ethanol.
浓度
100μg/mL
外观
A solution in ethanol
应用
实验应用
Potentially useful to study the mediation of EDHF (endothelium-derived hyperpolarizing factor) release
背景
分子式
C20H30O3
CAS号
131339-24-7
沸点
78° C
折射率
n20D 1.51 (Predicted)
制备和贮存
保存方式
Store at -20° C，2 year.
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