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Oligomycin
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产品介绍
产品介绍
产品信息
产品详情
Metabolism
简单描述
| Molecular Weight | 791.1 g/mol |
| Purity | 97% |
| Molecular Formula | Isomer A: C45H74O11 Isomer B: C45H72O12 Isomer C: C45H74O10 |
| CAS | 1404-19-9 |
| Solubility | Soluble in DMSO at 300mg/ml and EtOH at 200mg/ml. |
商品描述
Product Usage Information
Oligomycin is supplied as a lyophilized powder. For a 5 mM stock, reconstitute the 5 mg in 1.26 ml DMSO. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used at 0.5 - 10 μM for 0.5 - 8 hours.
背景
背景
During oxidative phosphorylation in mitochondria, the electron transport system pumps H+ from the matrix into the intermembrane compartment. This process generates a H+ gradient across the mitochondrial inner membrane. This H+ gradient is used to drive mitochondrial FoF1 ATPase to convert ADP to ATP. Oligomycin, an antibiotic from Streptomyces diastatochromogenes, blocks oxidative phosphorylation by binding to the Fo part of the ATPase to inhibit its activity (1-3).
1.Kagawa, Y. and Racker, E. (1966) J Biol Chem 241, 2461-6.
2.Kagawa, Y. and Racker, E. (1966) J Biol Chem 241, 2467-74.
3.Fessenden, J.M. and Racker, E. (1966) J Biol Chem 241, 2483-9.
翻译后修饰
unmodified
CAS号
1404-19-9
制备和贮存
保存方式
Store lyophilized or in solution at -20ºC, desiccated. Protect from light. In lyophilized form, the chemical is stable for 24 months. Once in solution, use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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