N-methyl Mesoporphyrin IX

N-methyl Mesoporphyrin IX is a transition state analog of porphyrin and an inhibitor of ferrochelatase.1 It inhibits ferrochelatase in mouse liver mitochondria in vitro and in vivo, leading to an accumulation of porphyrin in isolated liver mitochondria following administration of an intravenous dose of 80 nmol. N-methyl Mesoporphyrin IX has been used as a turn-on biosensor for target DNA sequences when used in complex with a G-quadruplex-forming sequence fused to a DNA sequence complementary to the target sequence.2 It has also been used to detect amyloid-β (1-40) (Aβ40) fibrils in vitro and in live PC12 cells overexpressing Aβ.3 N-methyl Mesoporphyrin displays excitation/emission maxima of 399/610 nm, respectively.4WARNING This product is not for human or veterinary use.

A ferrochelatase inhibitor and turn-on biosensor for DNA

580.7

≥95% (mixture of isomers)

Biochemicals/Small Molecule Inhibitors,Labeling & Detection/Fluorescent Probes

Formal_Name:8,13-diethyl-3,7,12,17,23-pentamethyl-21H,23H-porphine-2,18-dipropanoic acid

CC1=C2[NH]C(/C=C(C(CCC(O)=O)=C3C)\[N]=C3/C=C4[N](C)/C(C(C)=C\4CC)=C\C5=[N]/C(C(C)=C5CC)=C\2)=C1CCC(O

C35H40N4O4

142234-85-3

≥ 4 years

DMF: 20 mg/ml DMF:PBS (pH 7.2) (1:5): 0.17 mg/ml DMSO: 15 mg/ml