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Resiquimod (R-848)
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产品介绍
产品介绍
产品信息
简单描述
| Molecular Weight | 314.4 g/mol |
| Purity | >98% |
| Molecular Formula | C17H22N4O2 |
| CAS | 144875-48-9 |
| Solubility | Soluble in DMSO at 30 mg/ml or ethanol at 15 mg/ml with slight warming. |
商品描述
Product Usage Information
Resiquimod (R-848) is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 1.06 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
背景
背景
Resiquimod (R-848), an antiviral imidazoquinoline, has been shown to activate Toll-like receptor 7 (TLR7) and TLR8 via the MyD88-dependent interleukin 1 receptor (IL-1R)-TLR signaling pathway (1). Triggering of the TLR pathway leads to the activation of NF-κB and subsequent regulation of immune and inflammatory genes (2). Similar to CD40, treatment with Resiquimod (R-848) activates B cells and can induce nuclear translocation of NF-κB at a concentration of 1 μg/ml (3).
1.Jurk, M. et al. (2002) Nat Immunol 3, 499.
2.Medzhitov, R. et al. (1997) Nature 388, 394-7.
3.Bishop, G.A. et al. (2000) J Immunol 165, 5552-7.
分子式
C17H22N4O2
CAS号
144875-48-9
制备和贮存
保存方式
Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 2 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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