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Clobenpropit dihydrobromide
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产品介绍
产品介绍
产品信息
纯化方式
>99%
抗原名称
Histamine H3, Histamine H4, NMDA receptors
来源纯化
Synthetic
商品描述
VUF 9153;A Potent and Selective Antagonist of Histamine H3 Receptors and an Antagonist of NMDA Receptors;Clobenpropit dihydrobromide (#C-345) is a highly pure, synthetic, and biologically active compound.
分子量
470.65
生物活性
Clobenpropit dihydrobromide is a potent and selective antagonist/inverse agonist of the histamine H3 receptors (pA2 = 9.93), with partial agonist activity at histamine H4 receptors1. It is also an antagonist of the NMDA receptors (IC50 1 µM - 14 µM)2.
纯度
>99%
可溶性
Up to 100 mM in water. Centrifuge all product preparations before use (10000 x g 5 min).
浓度
10 nM – 10 µM.
形式
Lyophilized
背景
别名
3-(1H-imidazol-5-yl)propyl N'-[(4-chlorophenyl)methyl]carbamimidothioate;dihydrobromide.
背景
Clobenpropit dihydrobromide (VUF 9153) is a synthetic compound that acts as a potent, selective and competitive antagonist of the histamine H3 receptor and shows partial agonist activity towards the histamine H4 receptor. In addition, the compound acts as an antagonist of N-Methyl-d-aspartate (NMDA) receptors1 and displays IC50 values of 1 µM-14 µM2.
NMDA receptors are heterotetrameric channels formed by the assembly of two obligatory GluN1 and two GluN2/GluN3 subunits. They play an important role in a variety of cellular processes and brain functions such as, synaptic plasticity, addiction and stroke, and mediate physiological functions such as learning and memory formation and participates in glutamate excitotoxicity2.
Histamine H3 receptors are presynaptic G-protein coupled receptors that are expressed in the central nervous system. They regulate the release of several neurotransmitters, including biogenic amines, acetylcholine, GABA and glutamate3.
分子式
C14H19Br2ClN4S.
CAS号
145231-35-2
制备和贮存
存储溶液
Store at -20°C. It is recommended to prepare solutions afresh on the day of use, or aliquot stock solutions stored at -20°C to prevent repeated thawing and freezing.
保存方式
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at +4°C.;Store at -20°C. It is recommended to prepare solutions afresh on the day of use, or aliquot stock solutions stored at -20°C to prevent repeated thawing and freezing.
数据库链接
pubmed id
11213569
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