ZD 7155 (hydrochloride)

An AT1 receptor antagonist

ZD 7155 is a nonpeptide antagonist of the angiotensin II type 1 (AT1) receptor (IC50 = 3.3 nM).1 It inhibits angiotensin II-induced pressor responses in conscious normotensive rats in a dose-dependent manner and decreases mean arterial pressure in conscious spontaneously hypertensive rats when administered at a dose of 1.082 µmol/kg.2 ZD 7155 (10 mg/kg in the drinking water) improves motor nerve conduction velocity in the sciatic nerve in a rat model of streptozotocin-induced diabetic neuropathy.3 It decreases disease severity and NF-κB and activator protein 1 (AP-1) activation in a mouse model of LPS-induced acute lung injury when administered at a dose of 10 mg/kg.4

475

≥98%

O=C1N(CC2=CC=C(C3=C(C4=NN=NN4)C=CC=C3)C=C2)C5=CC(CC)=NC(CC)=C5CC1.Cl

C26H26N6O • HCl

146709-78-6

≥ 4 years

DMSO: 10 mM