Cyclo(RGDfK)

Cyclo(RGDfK) is a synthetic lipopeptide inhibitor of αvβ3 integrin (IC50 = 1.33 nM).1 Osteoblast cultures, which express αvβ5 and αvβ3 integrins, but not M21L cells that do not express these integrins, bind to cyclo(RGDfK)-coated surfaces. Cyclo(RGDfK) is taken up into tumors in vivo and in vitro and it has been polymerized or conjugated to various fluorophores, radiolabels, and peptide sequences for use in fluorescent and PET imaging to study tumor cell adhesion.2,3,1WARNING This product is not for human or veterinary use.

An inhibitor of αvβ3 integrin

603.7

≥95%

Biochemicals/Receptor Pharmacology/Antagonists,Labeling & Detection

Fluorescence

Formal_Name:cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-L-lysyl);Synonyms:Cyclo(Arg-Gly-Asp-D-Phe-Lys)

NC(NCCC[C@@H](C(NCC(N[C@H]1CC(O)=O)=O)=O)NC([C@H](CCCCN)NC([C@@H](CC2=CC=CC=C2)NC1=O)=O)=O)=N

C27H41N9O7

161552-03-0

≥ 4 years

DMSO: 15 mg/ml PBS (pH 7.2): 10 mg/ml