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产品介绍
产品信息
简单描述
A SERD
商品描述
AZD 9496 is a potent and selective estrogen receptor downregulator (SERD) with an IC50 value of 0.138 nM for estrogen receptor α (ERα) downregulation.1 It is selective for ERα compared to other nuclear hormone receptors with IC50 values of 0.0008, 0.54, 9.2, and 30 μM for ERα, progesterone receptor (PR), glucocorticoid receptor (GR), and androgen receptor (AR), respectively. AZD 9496 decreases ERα activity (IC50 = 0.282 nM), measured via quantification of downstream PR activity, and reduces proliferation of MCF-7 breast cancer cells (IC50 = 0.0398 nM). It also inhibits MCF-7 xenograft growth in mice in a dose-dependent manner.
分子量
442.5
纯度
≥98%
背景
结构式
CC(F)(C)CN1[C@H](C)CC2=C(NC3=C2C=CC=C3)[C@H]1C4=C(F)C=C(/C=C/C(O)=O)C=C4F
分子式
C25H25F3N2O2
CAS号
1639042-08-2
制备和贮存
保存
≥ 4 years
溶解方法
DMF: 30 mg/ml
DMSO: 30 mg/ml
Ethanol: 30 mg/ml
Ethanol:PBS (pH 7.2) (1:6): 0.14 mg/mL
保存方式
-20°C
参考图片
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