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产品介绍
产品介绍
产品信息
纯化方式
>99% (HPLC)
抗原名称
GluN2B
来源纯化
Synthetic
产品详情
A Potent and Selective Antagonist of GluN2B-Containing NMDA Receptors
商品描述
Ro 25-6981 maleate (#R-180) is a highly pure, synthetic, and biologically active compound.
分子量
455.55
生物活性
Ro 25-6981 maleate is a potent, NR2B-subunit selective, activity dependent antagonist of NMDA receptors, exhibiting a >5000-fold selectivity for NR2B-containing receptors (IC50 = 0.009 µM) over NR2A-containing receptors (IC50 = 52 µM) 1. Shows neuroprotective effects in vivo in injury2 and disease3 models, as well as anti-depressant, anti-inflammatory and other effects.
可溶性
Soluble up to 100 mM in DMSO. Soluble up to 10 mM in water with gentle warming. Centrifuge all product preparations before use (10000 x g 5 min).
浓度
0.01-100 µM.
形式
Lyophilized
背景
分子式
C26H33NO6 ( C22H29NO2 · C4H4O4 ).
CAS号
169274-78-6
制备和贮存
存储溶液
Store at -20°C. It is recommended to prepare solutions afresh on the day of use, or aliquot stock solutions stored at -20°C to prevent repeated thawing.
保存方式
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored desiccated at 4°C.
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