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产品介绍
产品介绍
产品信息
商品描述
17-DMAG, 17-dimethylaminoethylamino-17-demethoxygeldanamycin, is a synthetic derivative of the antibiotic Geldanamycin with lower hepatotoxicity than the parent antibiotic and higher potency and availability than the similar derivative 17-AAG . 17-DMAG is described to bind and inhibit the activity of Hsp90 (heat shock protein 90), a cellular chaperone that is over expressed in many cancers, and which participates in folding of proteins found in multiple signal transduction pathways.
分子量
616.75
纯度
≥98%
可溶性
Soluble in water, ethanol (10 mg/mL), and DMSO (>25 mg/mL).
IC50
hypoxia-induced HIF1 activation: IC50 = 3.6 nM (human AGS cells); SKBR3 : IC50 = 24 nM (human); HCT-116: IC50 = 57 nM (human); MCF7: IC50 = 71 nM (human)
Ki 数据
Heat shock protein HSP 90-alpha: Ki= 680 nM (human); His-tagged Hsp90: Ki= 250 nM
应用
实验应用
A synthetic Geldanamycin derivative and inhibitor of Hsp90
背景
别名
17-[2-(二甲基氨基)乙基氨基]-17-去甲基格尔德霉素
分子式
C32H48N4O8
CAS号
467214-20-6
沸点
810.53° C at 760 mmHg
PK值
pKa: 8.48, 9.02
密度
1.21 g/cm3
折射率
n20D 1.57
制备和贮存
保存方式
Store at -20° C
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