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TAS 103 (hydrochloride)
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产品介绍
产品介绍
产品信息
简单描述
TAS 103 is an inhibitor of DNA topoisomerase I and II (IC50s = 2 and 6.5 µM, respectively).1 It stabilizes topoisomerase I-DNA and topoisomerase II-DNA cleavable complexes in KB cells when used at a concentration of 3 µM. It is cytotoxic to P388 and KB cells (IC50s = 1.1 and 9.6 nM, respectively). TAS 103 (15, 26, and 45 mg/kg per day) reduces pulmonary metastasis in murine B16-BL6 melanoma and UV-2237M fibrosarcoma models of lung metastasis. It also reduces tumor growth in a variety of human cancer mouse xenograft models.WARNING This product is not for human or veterinary use.
商品描述
A DNA topoisomerase I and II inhibitor
分子量
406.3
纯度
≥98%
产品类型
Biochemicals/Small Molecule Inhibitors/Topoisomerases
背景
别名
Formal_Name:6-[[2-(dimethylamino)ethyl]amino]-3-hydroxy-7H-indeno[2,1-c]quinolin-7-one, dihydrochloride
研究领域
Cancer/Cell Death/Cell Migration & Metastasis/DNA Damage and Repair/Topoisomerase
结构式
O=C1C(C(NCCN(C)C)=NC2=C3C=CC(O)=C2)=C3C4=C1C=CC=C4.Cl.Cl
分子式
C20H19N3O2 • 2HCl
CAS号
174634-09-4
制备和贮存
保存
≥ 4 years
溶解方法
PBS (pH 7.2): 1 mg/ml
保存方式
-20°C
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