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Phalloidin
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产品介绍
产品介绍
产品信息
简单描述
Phalloidin is a heptapeptide phallotoxin produced by Amanita phalloides, the death cap mushroom. Phalloidin binds and stabilizes filamentous F-actin, preventing the dissociation of paired filaments and disturbing the natural equilibrium between filamentous (polymeric) and globular (monomeric) actin in the cell. The actin stabilized by Phalloidin is used by the cell for mechanical processes such as growth, scaffolding of the cytoskeleton, and locomotion, and disruption of this actin equilibrium destroys cellular functioning. Phalloidin can be fluorescently labeled and is commonly used to stain F-actin in cells.
参考文献 1. Wehland, J., et al. 1977. Proc. Natl. Acad. Sci. U.S.A. 74: 5613-5617. PMID: 3411632. Barden, J.A., et al. 1987. Eur. J. Biochem. 162: 583-588. PMID: 38301583. Cooper, J.A., 1987. J. Cell Biol. 105: 1473-1478. PMID: 3312229
分子量
788.9
纯度
≥90%
应用
实验应用
Phalloidin is a heptapeptide phallotoxin and F-actin stabilizing toxin that can prevent the dissociation of paired filaments in the cell.
背景
别名
Phalloidin is known as a heptapeptide phallotoxin.
结构式
CC1C(=O)NC2CC3=C(NC4=CC=CC=C34)SCC(C(=O)N5CC(CC5C(=O)N1)O)NC(=O)C(NC(=O)C(NC(=O)C(NC2=O)CC(C)(CO)O)C
分子式
C35H48N8O11S
CAS号
17466-45-4
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