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产品介绍
产品介绍
产品信息
简单描述
C8 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides.1 It is cytotoxic to U937 cells (IC50 = 17 μM) and induces nuclear DNA fragmentation 5- to 6-fold more potently than C8 ceramide (Item No. 62540).1,2 C8 D-threo Ceramide is a substrate for E. coli diacylglycerol kinase.1 It activates ceramide-activated protein kinase (CAPK) in U937 cells. C8 D-threo Ceramide also enhances V. cholerae cytolysin pore formation in liposome lipid membranes, as measured by calcein release, with a 50% release dose (RD50) value of ~5 μg/ml.3 [Matreya, LLC. Catalog No. 1810]WARNING This product is not for human or veterinary use.
商品描述
A bioactive sphingolipid
分子量
425.7
纯度
≥98%
产品类型
Biochemicals/Small Molecule Activators/Kinases,Labeling & Detection/Enzyme Substrates,Lipids/Sphingolipids
背景
别名
Formal_Name:N-[(1R,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-octanamide;Synonyms:D-threo Cer(d18:1/8:0) D-threo Ceramide (d18:1/8:0) N-octanoyl-D-threo-Sphingosine
研究领域
Cancer/Cell Death/DNA Damage and Repair,Lipid Biochemistry/Sphingolipids
结构式
OC[C@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC(CCCCCCC)=O
分子式
C26H51NO3
CAS号
175892-43-0
制备和贮存
保存
≥ 4 years
溶解方法
Chloroform: Soluble
DMF: Soluble
DMSO: Soluble
Ethanol: Soluble
保存方式
-20°C
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