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产品介绍
产品介绍
产品信息
简单描述
C8 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides.1 It is cytotoxic to U937 cells (IC50 = 10 μM) and, like C8 D-threo ceramide (Item No. 24391), induces nuclear DNA fragmentation 5- to 6-fold more potently than C8 L-erythro ceramide (Item No. 62540).2,1 C8 D-threo Ceramide also enhances V. cholerae cytolysin pore formation in liposome lipid membranes, as measured by calcein release, with a 50% release dose (RD50) value of ~30 μg/ml.3 [Matreya, LLC. Catalog No. 1830]WARNING This product is not for human or veterinary use.
商品描述
A bioactive sphingolipid
分子量
425.7
纯度
≥98%
产品类型
Biochemicals,Lipids/Sphingolipids
背景
别名
Formal_Name:N-[(1S,2S,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-octanamide;Synonyms:L-threo Cer(d18:1/8:0) L-threo Ceramide (d18:1/8:0) N-octanoyl-L-threo-Sphingosine
研究领域
Cancer/Cell Death/DNA Damage and Repair,Lipid Biochemistry/Sphingolipids
结构式
OC[C@@H]([C@@H](O)/C=C/CCCCCCCCCCCCC)NC(CCCCCCC)=O
分子式
C26H51NO3
CAS号
175892-44-1
制备和贮存
保存
≥ 4 years
溶解方法
Chloroform: Soluble
DMF: 5 mg/ml
DMSO: Soluble
Ethanol: Soluble
保存方式
-20°C
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