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AAF-CMK (trifluoroacetate salt)
AAF-CMK (trifluoroacetate salt)
品牌： Cayman
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对比
咨询分子式：
C16H22ClN3O3 • CF3COOH
分子量：
453.8
产品介绍
产品介绍
产品信息
简单描述
An inhibitor of TPPII
商品描述
Tripeptidyl peptidase II (TPPII) is a serine peptidase of the subtilisin-type which removes tripeptides from the free NH2 terminus of oligopeptides.1 AAF-CMK is an irreversible inhibitor of TPPII commonly used at 10-100 µM.2,3,4 It does not significantly interfere with the chymotrypsin-like activity of the proteasome. AAF-CMK also inhibits bleomycin hydrolase and puromycin-sensitive aminopeptidase when used at 50 µM.5
分子量
453.8
纯度
≥95%
背景
别名
N-Ala-Ala-Phe-CMK|Tripeptidyl Peptidase Inhibitor II
结构式
N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CC1=CC=CC=C1)C(CCl)=O)=O)=O.FC(F)(C(O)=O)F
分子式
C16H22ClN3O3 • CF3COOH
CAS号
184901-82-4
制备和贮存
保存
≥ 4 years
溶解方法
Water: 10 mg/ml
保存方式
-20°C
文献
文献
1.Macpherson, E.,Tomkinson, B.,Bålöw, R.M., et al. Supramolecular structure of tripeptidyl peptidase II from human erythrocytes as studied by electron microscopy, and its correlation to enzyme activity. Biochemistry Journal 248(1), 259-263 (1987).
2.Geier, E.,Pfeifer, G.,Wilm, M., et al. A giant protease with potential to substitute for some functions of the proteasome. Science 283(5404), 978-981 (1999).
3.Hilbi, H.,Puro, R.J. and Zychlinsky, A. Tripeptidyl peptidase II promotes maturation of caspase-1 in Shigella flexneri-induced macrophage apoptosis. Infection and Immunity 68(10), 5502-5508 (2000).
4.Lévy, F.,Burri, L.,Morel, S., et al. The final n-terminal trimming of a subaminoterminal proline-containing HLA class I-restricted antigenic peptide in the cytosol is mediated by two peptidases. Journal of Immunopharmacology 169(8), 4161-4167 (2002).
5.Stoltze, L.,Schirle, M.,Schwarz, G., et al. Two new proteases in the MHC class I processing pathway. Nature Immunology 1(5), 413-418 (2000).
2.Geier, E.,Pfeifer, G.,Wilm, M., et al. A giant protease with potential to substitute for some functions of the proteasome. Science 283(5404), 978-981 (1999).
3.Hilbi, H.,Puro, R.J. and Zychlinsky, A. Tripeptidyl peptidase II promotes maturation of caspase-1 in Shigella flexneri-induced macrophage apoptosis. Infection and Immunity 68(10), 5502-5508 (2000).
4.Lévy, F.,Burri, L.,Morel, S., et al. The final n-terminal trimming of a subaminoterminal proline-containing HLA class I-restricted antigenic peptide in the cytosol is mediated by two peptidases. Journal of Immunopharmacology 169(8), 4161-4167 (2002).
5.Stoltze, L.,Schirle, M.,Schwarz, G., et al. Two new proteases in the MHC class I processing pathway. Nature Immunology 1(5), 413-418 (2000).
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