ROC-325

An autophagy inhibitor

ROC-325 is an autophagy inhibitor.1 It inhibits autophagic flux and induces lysosomal deacidification and apoptosis in 786-O renal cell carcinoma cells when used at a concentration of 5 µM. ROC-325 decreases viability in a panel of 12 cancer cell lines, including renal, lung, pancreatic, and prostate cancer cells, with IC50 values ranging from 4.9 to 11 µM. It reduces tumor growth in a 786-O mouse xenograft model when administered at a dose of 50 mg/kg. ROC-325 also decreases the cytopathic effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in infected Vero E6 cells (EC50 = 3.28 µM).2

503.1

≥98%

O=C1C2=C(SC3=C1C(NCCN(CCNC4=C5C=CC(Cl)=CC5=NC=C4)C)=CC=C3C)C=CC=C2

C28H27ClN4OS

1859141-26-6

≥ 4 years

Chloroform: 10 mg/ml DMF: slightly soluble DMSO: slightly soluble Ethanol: slightly soluble