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1G244
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产品介绍
产品介绍
产品信息
抗原名称
DPP9:53 nM, DPP9:4.2 nM(ki), DPP8:14 nM, DPP8:0.9 nM(ki)
商品描述
1G244 is an inhibitor of DPP8/9 with antiatherosclerotic and antimyeloma properties. 1G244 had the IC50 values of 14 and 53 nM against DPP8 and DPP9, and The Ki values for 1G244 were 0.9 and 4.2 nM for DPP8 and DPP9
纯度
98%
可溶性
DMSO:225.0 mg/mL (445.9 mM)
In vitro(体外研究)
1G244 (0-100 μM) dose-dependently decreased viable cell number of five multiple myeloma cell lines as well as three T-cell lymphoma cell lines[2].
In vivo(体内研究)
The apoE−/− mice treated with 1G244 (1G244 dissolved in 75% PEG 300, 2 mg/kg) showed that 1G244 reduced the area of advanced atherosclerotic lesions by about 14%[1]. 1G244 was administered subcutaneously into mice at 30 mg/kg once a week, administration of 1G244 apparently suppressed the subcutaneous growth of MM.1 S cells[2].
背景
分子式
C29H30F2N4O2
CAS号
847928-32-9
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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