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WHI-P131
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产品介绍
产品介绍
产品信息
简单描述
| Molecular Weight | 333.8 g/mol |
| Purity | >98% |
| Molecular Formula | C16H15N3O3 • HCl |
| CAS | 202475-60-3 |
| Solubility | Soluble in DMSO at 50 mg/ml. |
商品描述
Product Usage Information
WHI-P131 is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 998 μl of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
背景
背景
WHI-P131 is a potent and selective inhibitor of Janus kinase 3 (Jak3) (IC50 = 78 μM) and glioblastoma cell adhesion and migration (1,2). This novel quinazoline derivative inhibits the enzymatic activity of constitutively active Jak3 without affecting Jak1, Jak2, or other family tyrosine kinases (1). WHI-P131 has also been shown to inhibit thrombin-induced tyrosine phosphorylation of Stat1 and Stat3. These properties make this compound useful when studying different diseases such as acute lymphoblastic leukemia, glioblastoma multiforme, and thromboembolism (1-3).
1.Sudbeck, E.A. et al. (1999) Clin Cancer Res 5, 1569-82.
2.Narla, R.K. et al. (1998) Clin Cancer Res 4, 2463-71.
3.Tibbles, H.E. et al. (2001) J Biol Chem 276, 17815-22.
分子式
C16H15N3O3 • HCl
CAS号
202475-60-3
制备和贮存
保存方式
Store lyophilized at 4ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 2 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
参考图片
Chemical structure of WHI-P131.
Western blot analysis of extracts from KARPAS 299 cells, untreated (-) or treated with WHI-P131 (50 μM, 1hr; +), using Phospho-Stat3 (Tyr705) (D3A7) XP® Rabbit mAb #9145 (upper), Stat3 (D3Z2G) Rabbit mAb #12640 (middle), or β-Actin (D6A8) Rabbit mAb #8457 (lower).
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