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产品介绍
产品信息
简单描述
NS 2028 is a potent, specific, and irreversible inhibitor of soluble guanylyl cyclase (IC50 = 30 nM for basal and 200 nM for NO-stimulated enzyme activity; IC50 = 17 nM for S-nitrosoglutathione-enhanced soluble guanylyl cyclase activity in homogenates of mouse cerebellum).
参考文献 1. Olesen, S P., et al., 1998. Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase. British journal of pharmacology. 123(2): 299-309. PMID: 9489619 2. Fleming, I., et al., 1999. Isometric contraction induces the Ca2+-independent activation of the endothelial nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America. 96(3): 1123-8. PMID: 9927704

分子量
269.05

应用
实验应用
NS 2028 is a potent, specific, and irreversible inhibitor of soluble guanylyl cyclase

背景
别名
8-Bromo-4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one

结构式
C1C2=NOC(=O)N2C3=C(O1)C=CC(=C3)Br

分子式
C9H5BrN2O3

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