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产品介绍
产品介绍
产品信息
简单描述
(R)-KT109 is the (R) isomer of the diacylglycerol lipase β (DAGLβ) inhibitor KT109 (Item No. 18933).1 (R)-KT109 is an inhibitor of DAGLβ (IC50 = 0.79 nM) and of DAGLα-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol (Item No. 10008650; IC50 = 25.12 nM). It also inhibits α/β-hydrolase domain-containing protein 6 (ABHD6) with an IC50 value of 2.51 nM. (R)-KT109 is more potent at DAGLβ, DAGLα, and ABHD6 than (S)-KT109 (Item No. 25683).WARNING This product is not for human or veterinary use.
商品描述
An inhibitor of DAGLβ, DAGLα, and ABHD6
分子量
422.5
纯度
≥98%
产品类型
Biochemicals/Small Molecule Inhibitors/Glycerolipid Lipases
背景
别名
Formal_Name:(4-[1,1'-biphenyl]-4-yl-1H-1,2,3-triazol-1-yl)[(2R)-2-(phenylmethyl)-1-piperidinyl]-methanone
研究领域
Lipid Biochemistry/Endocannabinoid/Endocannabinoid-like/Glycerolipids/Lipases,Neuroscience
结构式
O=C(N1N=NC(C2=CC=C(C3=CC=CC=C3)C=C2)=C1)N4[C@@H](CC5=CC=CC=C5)CCCC4
分子式
C27H26N4O
CAS号
2055172-60-4
制备和贮存
保存
≥ 4 years
溶解方法
DMF: 10 mg/ml
DMSO: 10 mg/ml
保存方式
-20°C
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