SM-102

无

An ionizable cationic lipid

SM-102 is an ionizable cationic lipid (pKa = 6.68) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA and plasmid DNA in vitro and in vivo.1,2 It inhibits inward-rectifying potassium currents mediated by human-ether-a-go-go (hERG), also known as Kv11.1, in GH3 rat pituitary cells and MA-10 mouse Leydig cells (IC50s = 108 and 98 µM, respectively).3 Administration of luciferase mRNA in SM-102-containing LNPs induces hepatic luciferase expression in mice.1 LNPs containing SM-102 and Q1-SM-102 (Item No. 41239) as a cationic lipid pair (CLP) and encapsulating a luciferase reporter induce luciferase expression in the lungs and spleen in mice.4 Intramuscular immunization of LNPs containing SM-102 and encapsulating mRNA encoding the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein increases serum SARS-CoV-2 spike glycoprotein-specific IgG titers in mice.5 LNPs containing SM-102 and encapsulating mRNA encoding β-catenin increase bone volume in a mouse model of tibia fracture repair when administered via injection to the fracture callus.6 Formulations containing SM-102 have been used in the development of LNPs for delivery of mRNA-based vaccines. Read our statement on SM-102 for research use only

710.2

≥98%

8-[(2-羟基乙基)[6-氧代]6-(十一烷氧基)己基]氨基]1-辛基壬基辛酸酯≥98%杂质≤2%

CAY10779|Lipid H|LNP-102

OCCN(CCCCCCCC(OC(CCCCCCCC)CCCCCCCC)=O)CCCCCC(OCCCCCCCCCCC)=O

C44H87NO5

2089251-47-6

≥ 1 year

Chloroform: 100 mg/ml Ethanol: 100 mg/ml

1170