全部商品分类首页
NU 6027
用小程序，查商品更便捷
产品介绍
产品介绍
产品信息
简单描述
NU 6027 inhibits both CDK1 and CDK2 with IC50 values of 2.9 and 2.2 µM, respectively.1 It has been shown to inhibit cellular ataxia telangiectasia mutated and Rad3-related kinase activity (IC50 = 6.7 µM) and impair G2/M arrest in various human cancer cells, potentiating the cytotoxic effects of DNA-damaging, anticancer agents such as cisplatin.2WARNING This product is not for human or veterinary use.
商品描述
A CDK and ATR inhibitor
分子量
251.3
纯度
≥98%
产品类型
Biochemicals/Kinase Inhibitors/ATR/CDKs/Small Molecule Inhibitors/Kinases
背景
别名
Formal_Name:6-(cyclohexylmethoxy)-5-nitroso-2,4-pyrimidinediamine
研究领域
Cancer/Cell Cycle/G2/M/Cell Death/Cell Signaling/ATM Signaling
结构式
NC1=NC(N)=C(N=O)C(OCC2CCCCC2)=N1
分子式
C11H17N5O2
CAS号
220036-08-8
制备和贮存
保存
≥ 4 years
溶解方法
DMF: 5 mg/ml
DMSO: 10 mg/ml
DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml
Ethanol: 1 mg/ml
保存方式
-20°C
文献
文献
1.Sayle, K.L.,Bentley, J.,Boyle, F.T., et al. Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2. Bioorganic & Medicinal Chemistry Letters 13(18), 3079-3082 (2003).
2.Peasland, A.,Wang, L.Z.,Rowling, E., et al. Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines. British Journal of Cancer 105(3), 372-381 (2011).
2.Peasland, A.,Wang, L.Z.,Rowling, E., et al. Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines. British Journal of Cancer 105(3), 372-381 (2011).
声明 ：本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。