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产品介绍
产品介绍
产品信息
简单描述
6-hydroxy Melatonin is an active metabolite of melatonin (Item No. 14427).1,2,3,4,5 It is formed from melatonin by the cytochrome P450 (CYP) isoform CYP1A2 in human liver microsomes.6 6-hydroxy Melatonin is a melatonin 1A (MT1A), MT1B, and MT2 receptor agonist.1,2 It inhibits dopamine release from isolated rabbit retina (IC50 = 0.0016 µM).3 6-hydroxy Melatonin (10 and 100 µM) reduces increases in the levels of NF-κB, IL-6, and IL-8 and decreases in glutathione (GSH) levels in LPS- and peptidoglycan G-stimulated human umbilical vein endothelial cells (HUVECs) in an in vitro model of sepsis.4 It reduces iron-induced lipid oxidation in rat hippocampal homogenate when administered at a dose of 10 mg/kg.5WARNING This product is not for human or veterinary use.
商品描述
An active metabolite of melatonin
分子量
248.3
纯度
≥95%
产品类型
Biochemicals/Antioxidants/Receptor Pharmacology/Agonists
背景
别名
Formal_Name:N-[2-(6-hydroxy-5-methoxy-1H-indol-3-yl)ethyl]-acetamide;Synonyms:6-OHM
研究领域
Cardiovascular System/Vasculature/Endothelium,Cell Biology/Cell Signaling/NF-κB Signaling,Epigenetics, Transcription, & Translation/Transcription Factors,Immunology & Inflammation/Innate Immunity/Sepsis/Shock,Neuroscience/Ophthalmology,Oxidative Stress & Reactive Species/Antioxidant Activity/Lipid Peroxidation/Reactive Sulfur/Glutathione
结构式
COC1=C(O)C=C(NC=C2CCNC(C)=O)C2=C1
分子式
C13H16N2O3
CAS号
2208-41-5
制备和贮存
保存
≥ 4 years
溶解方法
DMF: 30 mg/ml
DMSO: 30 mg/ml
DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
Ethanol: 20 mg/ml
保存方式
-20°C
文献
文献
1.Dubocovich, M.L. Melatonin receptors: Are there multiple subtypes? Trends Pharamacol. Sci. 16(2), 50-56 (1995).
2.Boutin, J.A.,Audinot, V.,Ferry, G., et al. Molecular tools to study melatonin pathways and actions. Trends in Pharamacological Sciences 26(8), 412-419 (2005).
3.Alvarez-Diduk, R.,Galano, A.,Tan, D.X., et al. N‑Acetylserotonin and 6‑hydroxymelatonin against oxidative stress: Implications for the overall protection exerted by melatonin. J. Phys. Chem. B 119(27), 8535-8543 (2015).
4.Maharaj, D.S.,Walker, R.B.,Glass, B.D., et al. 6-Hydroxymelatonin protects against cyanide induced oxidative stress in rat brain homogenates. J. Chem. Neuroanat. 26(2), 103-107 (2003).
2.Boutin, J.A.,Audinot, V.,Ferry, G., et al. Molecular tools to study melatonin pathways and actions. Trends in Pharamacological Sciences 26(8), 412-419 (2005).
3.Alvarez-Diduk, R.,Galano, A.,Tan, D.X., et al. N‑Acetylserotonin and 6‑hydroxymelatonin against oxidative stress: Implications for the overall protection exerted by melatonin. J. Phys. Chem. B 119(27), 8535-8543 (2015).
4.Maharaj, D.S.,Walker, R.B.,Glass, B.D., et al. 6-Hydroxymelatonin protects against cyanide induced oxidative stress in rat brain homogenates. J. Chem. Neuroanat. 26(2), 103-107 (2003).
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