Anisomycin

Anisomycin is a phenylpyrolidine derivative shown to strongly activate the stress-induced MAP kinases JNK and p38. This activity results in the induction of the immediate-early genes: c-Fos, c-Jun, Fos B, Jun B and Jun D, and enhanced phosphorylation of p54/nrb, ATF-2, ERK, Caldesmon, IRS-1 and IRS-2. This compound behaves as a true signaling agonist, and has been implicated to play an important role in hyperosmolarity and UV-stimulated responses. Anisomycin has also been shown to increase the phosphorylation of p70 S6 kinase α. 参考文献 1. Kochi, S.K. and Collier, R.J. 1993. Exp. Cell Res. 208: 296-302. PMID: 8359223 2. Kardalinou, E., et al. 1994. Mol. Cell. Biol. 14: 1066-1074. PMID: 8289787 3. Kyriakis, J.M., et al. 1994. Nature. 369: 156-160. PMID: 8177321 4. Sánchez, I., et al. 1994. Nature. 372: 794-798. PMID: 7997269 5. Hazzalin, C.A., et al. 1998. Mol. Cell. Biol. 18: 1844-1854. PMID: 9528756 6. Okulski, P., et al. 2002. Neuroscience. 114: 1-5. PMID: 12207948 7. Rudy, J.W., et al. 2006. Learn. Mem. 13: 1-3. PMID: 16452648 8. Mawji, I.A., et al. 2007. Cancer Res. 67: 8307-8315. PMID: 17804746 9. Kukushkin, A.N., et al. 2008. J. Cell. Biochem. 103: 1005-1012. PMID: 17647273

265.30

≥98%

powder

Anisomycin is activator of JNK (c-Jun N-terminal kinases) and p38

Flagecidin; 2-(p-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate

CC(=O)O[C@@H]1[C@H](CN[C@@H]1CC2=CC=C(C=C2)OC)O

C14H19NO4

22862-76-6