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DX3-213B
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产品介绍
产品介绍
产品信息
简单描述
DX3-213B is an inhibitor of mitochondrial complex I, also known as NADH dehydrogenase (IC50 = 3.6 nM).1 It inhibits the proliferation of MiaPaCa-2 cells cultured in galactose- but not glucose-containing media (IC50s = 9.1 and >3,000 nM, respectively). DX3-213B (10 mg/kg) reduces tumor volume in a Panc02 murine pancreatic ductal adenocarcinoma model.WARNING This product is not for human or veterinary use.
商品描述
A mitochondrial complex I inhibitor
分子量
478.6
纯度
≥95%
产品类型
Biochemicals/Small Molecule Inhibitors/Oxidative Phosphorylation
背景
别名
Formal_Name:(R)-(4,4-difluoropiperidin-1-yl)(1-((4-(isopropylsulfonyl)phenyl)sulfonyl)piperidin-3-yl)methanone
研究领域
Cancer/Metabolism,Cell Biology/Mitochondrial Biology
结构式
O=S(N1C[C@@H](CCC1)C(N2CCC(F)(CC2)F)=O)(C3=CC=C(C=C3)S(C(C)C)(=O)=O)=O
分子式
C20H28F2N2O5S2
CAS号
2749555-66-4
制备和贮存
保存
≥ 2 years
溶解方法
DMF: 2 mg/ml
DMSO: 3 mg/ml
Ethanol: 2 mg/ml
PBS (pH 7.2): insol
保存方式
-20°C
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