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Altenusin
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产品介绍
产品介绍
产品信息
简单描述
Altenusin is a polyphenol fungal metabolite originally isolated from the fungus Alternaria that has diverse biological activities.1,2 It inhibits Src kinase with an IC50 value of 20 nM.3 Altenusin inhibits fibrillization of recombinant tau fragments in vitro and phosphorylation of tau in SH-SY5Y cells expressing human P301L mutant tau when used at a concentration of 10 μM.1 It is an agonist of the farnesoid X receptor (FXR; EC50 = 3.2 μM) that reduces blood glucose, serum insulin, and serum cholesterol levels, as well as hepatic lipogenic gene expression and steatosis, in a high fat diet-induced mouse model of obesity when administered at 30 mg/kg per day.2 Altenusin also has antioxidant and antifungal properties.WARNING This product is not for human or veterinary use.
商品描述
A fungal metabolite with diverse biological activities
分子量
290.3
纯度
≥98%
产品类型
Biochemicals/Kinase Inhibitors/SRC Family/Receptor Pharmacology/Agonists/Small Molecule Inhibitors/Kinases,Natural Products/Microbial Metabolites
背景
别名
Formal_Name:3,4',5'-trihydroxy-5-methoxy-2'-methyl-[1,1'-biphenyl]-2-carboxylic acid;Synonyms:Alutenusin
研究领域
Endocrinology & Metabolism/Hormones & Receptors/FXRs & LXRs/Metabolic Diseases/Diabetes/Dyslipidemias/Obesity,Immunology & Inflammation,Infectious Disease/Fungal Diseases,Neuroscience/Neurodegenerative Disorders/Alzheimer’s Disease,Oxidative Stress & Reactive Species/Antioxidant Activity
结构式
COC1=CC(C2=C(C)C=C(O)C(O)=C2)=C(C(O)=O)C(O)=C1
分子式
C15H14O6
CAS号
31186-12-6
制备和贮存
保存
≥ 4 years
溶解方法
DMSO: soluble
Ethanol: soluble
Methanol: soluble
保存方式
-20°C
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