CFM 4

CFM 4 is an inhibitor of the protein-protein interaction between anaphase-promoting complex subunit 2 (APC2) and cell cycle and apoptosis regulatory protein 1 (CARP-1).1 It inhibits the binding of APC2 to CARP-1 (IC50 = 0.75 µM). CFM 4 reduces the proliferation of a variety of breast, prostate, and colon cancer cells in a concentration-dependent manner. It induces cell cycle arrest at the G0 phase in MDA-MB-468 breast cancer cells and apoptosis in T47D breast cancer cells when used at a concentration of 20 µM. Nanostructure lipid carrier-encapsulated CFM 4 (40 mg/kg every other day) reduces tumor growth in an A549 non-small cell lung cancer (NSCLC) mouse xenograft model.2WARNING This product is not for human or veterinary use.

An inhibitor of the APC2-CARP-1 protein-protein interaction

405.9

≥98%

Biochemicals

Formal_Name:1-[(2-chlorophenyl)methyl]-5′-phenyl-spiro[3H-indole-3,2′(3′H)-[1,3,4]thiadiazol]-2(1H)-one

O=C1N(CC2=C(Cl)C=CC=C2)C3=C(C14SC(C5=CC=CC=C5)=NN4)C=CC=C3

C22H16ClN3OS

331458-02-7

≥ 4 years

DMSO: 25 mg/ml