全部商品分类首页
Hypophyllanthin
用小程序，查商品更便捷
产品介绍
产品介绍
产品信息
简单描述
Hypophyllanthin is an active principle of P. amarus, a plant studied for its potential to treat hepatotoxicity.1 In Caco-2 cells 100 µM hypophyllanthin has been shown to reversibly inhibit P-glycoprotein (also known as multidrug resistance protein 1 (MDR1)) function without effect on MDR2 activity.2WARNING This product is not for human or veterinary use.
商品描述
A P-glycoprotein inhibitor
分子量
430.5
纯度
≥98%
产品类型
Biochemicals/Transporter & Exchanger Modulators,Natural Products
背景
别名
Formal_Name:(7S,8S,9R)-9-(3,4-dimethoxyphenyl)-6,7,8,9-tetrahydro-4-methoxy-7,8-bis(methoxymethyl)-naphtho[1,2-d]-1,3-dioxole;Synonyms:NSC 619044
研究领域
Toxicology & Xenobiotic Metabolism/Multidrug-Resistance Proteins
结构式
COC[C@@H]1[C@@H](COC)CC(C=C(OC)C2=C3OCO2)=C3[C@H]1C4=CC(OC)=C(OC)C=C4
分子式
C24H30O7
CAS号
33676-00-5
制备和贮存
保存
≥ 4 years
溶解方法
DMF: 30 mg/ml
DMSO: 10 mg/ml
Ethanol: 0.2 mg/ml
保存方式
-20°C
文献
文献
1.Murali, B.,Amit, A.,Anand, M.S., et al. An improved HPLC method for estimation of phyllanthin and hypophyllanthin in Phyllanthus amarus. Journal of Natural Remedies 1(1), 55-59 (2001).
2.Sukhaphirom, N.,Vardhanabhuti, N.,Chirdchupunseree, H., et al. Phyllanthin and hypophyllanthin inhibit function of P-gp but not MRP2 in Caco-2 cells. Journal of Pharmacy and Pharmacology 65, 292-299 (2012).
2.Sukhaphirom, N.,Vardhanabhuti, N.,Chirdchupunseree, H., et al. Phyllanthin and hypophyllanthin inhibit function of P-gp but not MRP2 in Caco-2 cells. Journal of Pharmacy and Pharmacology 65, 292-299 (2012).
声明 ：本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。