o,p‘-DDE

A metabolite and degradation product of the pesticide DDT

o,p'-DDE is a metabolite and degradation product of the organochlorine pesticide DDT.1 It accumulates in smallmouth buffalo, channel catfish, and largemouth bass as well as sediment in the Huntsville Spring Branch-Indian Creek tributary system surrounding a DDT manufacturing plant where it is considered a persistent organic pollutant (POP). o,p'-DDE inhibits estrogen binding to rainbow trout estrogen receptors (rtERs) with an IC50 value of 3.2 μM.2 It induces concentration-dependent secretion of estradiol by granulosa and theca cell co-cultures isolated from porcine ovarian follicles.3 In ovo exposure to o,p'-DDE increases degeneration of ovarian follicles and reduces testicular size in Japanese medaka (O. latipes).4

318

≥95%

o,p'-Dichlorodiphenyldichloroethylene|2,4’-DDE|NSC 59908

ClC1=CC=C(/C(C2=CC=CC=C2Cl)=C(Cl)\Cl)C=C1

C14H8Cl4

3424-82-6

≥ 4 years

Chloroform: Heated Methanol: Slightly Soluble

3077