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产品介绍
产品介绍
产品信息
简单描述
2-hydroxy Estrone is an active metabolite of the endogenous estrogen estrone (Item No. 10006485).1 It is formed from estrone primarily by the cytochrome P450 (CYP) isoforms CYP1A2, CYP1A1, and CYP1B1 and metabolized to 2-methoxy estrone (Item No. 34155) by catechol-O-methyltransferase (COMT). 2-hydroxy Estrone (10 µM) inhibits the proliferation of estrogen receptor-positive MCF-7, but not estrogen receptor-negative MDA-MB-231, breast cancer cells cultured with the COMT inhibitor quinalizarin.2 It inhibits iron-ADP-adriamycin complex-induced lipid peroxidation of liposomes prepared from rat liver microsomes (IC50 = 2.7 µM).3WARNING This product is not for human or veterinary use.
商品描述
An active metabolite of estrone
分子量
286.4
纯度
≥95%
产品类型
Biochemicals/Antioxidants,Lipids/Sterol Lipids
背景
别名
Formal_Name:2,3-dihydroxy-estra-1,3,5(10)-trien-17-one;Synonyms:Catecholestrone 2-hydroxy E1 2-OHE1
研究领域
Cancer,Endocrinology & Metabolism/Hormones & Receptors/Estrogens & Progestins,Oxidative Stress & Reactive Species/Antioxidant Activity/Lipid Peroxidation
结构式
C[C@@]12[C@](CCC2=O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC(O)=C(O)C=C4CC3
分子式
C18H22O3
CAS号
362-06-1
制备和贮存
保存
≥ 4 years
溶解方法
DMF: 30 mg/ml
DMSO: 30 mg/ml
Ethanol: 30 mg/ml
Ethanol:PBS (pH 7.2) (1:2): 0.33 mg/ml
保存方式
-20°C
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